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Surface-enhanced Raman spectroscopy (SERS) is a valuable technique for the direct detection of analytes or materials characterization, with wide applications forbiosensing and (bio)-imaging. (1) The selection of appropriate plasmonic SERS substrates can amplify Raman signals up to 1 × 1015 times. (2−4) Among the materials with SERS activity, gold, (5,6) silver, (7) and copper (8) with different nanostructures and morphologies are the most promising.
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