BMI Body mass index CAKUT Congenital abnormalities of the kidney and urinary tract CHD Congenital heart disease CHI Children's Health Ireland CKD Chronic kidney disease DS Down syndrome eGFR Estimated glomerular filtration rate IDMS Isotope dilution mass spectrometry iPMS Integrated Patient Management System STROBE Strengthening the Reporting of Observational Studies in Epidemiology 1 Introduction Down syndrome (DS) is the most common congenital chromosomal abnormality, occurring in 1 in 444...