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INTRODUCTION Genome-wide paternal uniparental disomy (GW-UPDpat) refers to the presence of two copies of all chromosomes, where all nuclear chromosomes are derived from the father and none are from the mother.
Objectives Complete hydatidiform mole with a coexisting fetus (CHMCF) is associated with high risk for pregnancy complications including fetal loss, pre-eclampsia, preterm birth, and invasive trophoblastic disease. We report on SNP-based prenatal cell free DNA (cfDNA) screening reported as having an atypical SNP pattern compatible with CHMCF. Methods The study included cfDNA samples received 6/1/2014 - 11/30/2023.
What are the novel findings of this work? This propensity score analysis found that a documented clinician recommendation for low-dose aspirin (LDA) in pregnancy was associated with an increased risk for postpartum hemorrhage and placental abruption in a large, contemporary birth population. The number needed to harm with LDA was 1 in 79 for postpartum hemorrhage and 1 in 287 for placental abruption. What are the clinical implications of this work?
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