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Abstract Norepinephrine (NE) is a critical neuromodulator that dynamically shapes brain states and behavior. Genetically encoded fluorescent NE indicators have enabled in vivo visualization of NE release, yet their limited sensitivity and spectral flexibility constrain widespread use in complex experimental paradigms. Here we developed next-generation green and red fluorescent NE indicators, named nLightG2 and nLightR2, respectively.
1 INTRODUCTION The application of the scientific method to neuroscience allows us to understand and make predictions about the ways in which complex aspects of animal behavior are encoded and coordinated by the brain. To do so, scientists observe and experiment to understand causalities, formulate and test hypotheses.
Labouesse, M. A. & Patriarchi, T. A. A versatile GPCR toolkit to track in vivo neuromodulation: not a one-size-fits-all sensor. Neuropsychopharmacology 46, 2043–2047 (2021). PubMed PubMed Central Google Scholar Wu, Z., Lin, D. & Li, Y. Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. Nat. Rev. Neurosci. 23, 257–274 (2022). CAS PubMed Google Scholar Patriarchi, T. et al. An expanded palette of dopamine sensors for multiplex imaging in vivo. Nat. Methods 17, 1147–1155 (2020).
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