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Articles by van der Ende
Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia - Molecular Neurodegeneration
As part of our previous work [29], the discovery cohort (total = 617; Table 1) included CSF samples from patients diagnosed with FTD (n = 189), AD dementia (n = 232), and cognitively normal individuals (CON, n = 196). Most of the samples were selected from the Amsterdam Dementia Cohort (ADC; 120 FTD, 214 AD, 190 CON) [37].
Effects of background noise on autonomic arousal (skin conductance level)
Topics Acoustical properties, Auditory system, Acoustic noise, Acoustic signal processing, Light emitting diodes, Heating, ventilation, and air-conditioning, MATLAB, Diseases and conditions, Autonomic nervous system, Analysis of variance There is a growing interest in the effects of autonomic arousal (AA) on human behavior (Bellato , 2020; Critchley, 2005; Diamond , 2007).
The completely renewed and upgraded neutron reflectometer at the TU Delft Reactor Institute
Topics Neutron reflectometry, Reflectometry, Elastic neutron scattering, Thin films, Particle beams Neutron reflectometry is a technique that can be used to obtain information about the thickness, composition, and roughness of thin films and other layered structures with layer thicknesses from a few to over hundreds of nanometers.
Genetic insights into resting heart rate and its role in cardiovascular disease
van de Vegte, Y. J. et al. (2023) Genetic insights into resting heart rate and its role in cardiovascular disease. Nature Communications, 14(1), 4646. (doi: 10.1038/s41467-023-39521-2) (PMID:37532724) (PMCID:PMC10397318) Text 305313.pdf - Published Version Available under License Creative Commons Attribution. 4MB Abstract Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies.
CSF proteomics in autosomal dominant Alzheimer’s disease highlights parallels with sporadic disease
Autosomal dominant Alzheimer’s disease (ADAD) offers a unique opportunity to study pathophysiological changes in a relatively young population with few comorbidities. A comprehensive investigation of proteome changes occurring in ADAD could provide valuable insights into AD-related biological mechanisms and uncover novel biomarkers and therapeutic targets. Furthermore, ADAD might serve as a model for sporadic AD, but in-depth proteome comparisons are lacking.
Leishmania Animal Models Used in Drug Discovery: A Systematic Review
Abstract : Simple Summary Animals are frequently used to determine whether new compounds have the potential to be used as drugs against the parasitic disease leishmaniasis. There is, however, no consensus on the best animal model, and many different ones are used. This review explored the many different models and identified their strengths and weaknesses.
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