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Introduction With the introduction of machine perfusion for organ preservation, a new era within transplantation medicine has emerged. While conventional static cold storage is still the most commonly employed method for organ preservation, it is associated with a number of limitations, including tissue damage by prolonged hypothermia, limited possibilities for quality assessment, inevitable ischemia-reperfusion injury upon rewarming and reperfusion, and limited options for organ reconditioning.
Introduction Since the criteria for determination of brain death were introduced in 1968 (1), heart transplantation relied on donor hearts from donation after brain death (DBD). Use of hearts from controlled donation after circulatory death (cDCD), where death is defined by the irreversible cessation of circulation (2), has proven to increase the availability of donor hearts of acceptable quality (3–7).
S E. Kaffka Genaamd Dengler1, M T. Vervoorn1, M Brouwer1, Jeroen De Jonge2 and Niels P. van der Kaaij1* 1Department of Cardiothoracic Surgery, University Medical Center Utrecht, Netherlands 2Erasmus Medical Center Transplant Institute, Department of Surgery, Netherlands The final, formatted version of the article will be published soon.
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