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The Dutch ABOARD Cohort is part of the overarching ABOARD-project, a public-private project with over 30 partners with the ambition to prepare for a future with personalized medicine for ADRD (www.aboard-project.nl) [10, 11].
Abstract Alzheimer’s disease and related dementias (ADRD) take 20 to 30 years to develop, yet setting up studies or registries that take into account the entire disease trajectory is difficult and time consuming. Moreover, prediction models are often based on selected research populations and their outcomes may not be most relevant to patients’ daily lives.
Brain, Sep 2023 The amyloid cascade hypothesis has strongly impacted the Alzheimer's disease research agenda and clinical trial designs over the past decades, but precisely how amyloid-β pathology initiates the aggregation of neocortical tau remains unclear. We cannot exclude the possibility of a shared upstream process driving both amyloid-β and tau in an independent manner instead of there being a causal relationship between amyloid-β and tau.
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