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Abstract The current classification of porcine immunoglobulin G (IgG) subclasses relies on phylogenetic analysis of gene sequences, resulting in a nomenclature that is inapt to predict biological function. Here, we propose a revised, functionality-based nomenclature derived from a comprehensive re-analysis of Fc domain interaction motifs and in vitro effector function assays.
Hans Van der Weken1, Hamid R. Jahantigh2, 3, Eric Cox1 and Bert Devriendt1* 1Ghent University, Belgium 2Emory University, United States 3Interdisciplinary Department of Medicine - Section of Occupational Medicine, University of Bari, Italy The final, formatted version of the article will be published soon.
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