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Single-cell datasets Three different scRNA-seq datasets were included in this study, both for benchmarking the associations and for combined meta-analysis of co-expression QTLs. All five datasets from the three studies were generated from human PBMCs and are referred to by their first author: the Oelen dataset (n = 104 donors) [11], the van der Wijst dataset (n = 45 donors) [10], and the van Blokland dataset (n = 38 cardiac patients) [20].
4.7 Changes in methods between SR1.5 and AR6 WGIII and their implications The most recent and most rigorous scenario assessment until AR6 was done in SR1.5. Insights from IAM-based assessment have influenced the global science-policy discourse (van Beek et al., 2020, 2022) and are even referred to in outcomes from informed ambitions in the Glasgow Climate Pact (UNFCCC, 2021).
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