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Articles by van Eijk
Clinical effects of multi-strain probiotics in extremely preterm infants: a multicenter pre-post implementation study in the Netherlands
In this multicenter retrospective study, we observed that administration of a multi-strain probiotic product (ProPrems®) to extremely preterm infants was associated with a significant reduction in the incidence of NEC, shorter tFEF, and improved early postnatal growth in the first month of life. Importantly, the observed reduction in NEC was consistent across participating centers, and the beneficial effects on feeding and growth were supported by both unadjusted and multivariate analyses.
Interpreting Hierarchical Composite Endpoints with Survival and Longitudinal Outcomes: Application to Amyotrophic Lateral Sclerosis Trials
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The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes
Biffi G, Tannahill D, McCafferty J, Balasubramanian S. Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem. 2013;5:182–6. Google Scholar Henderson A, Wu Y, Huang YC, Chavez EA, Platt J, Johnson FB, et al. Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res. 2014;42:860–9. Google Scholar Di Antonio M, Ponjavic A, Radzevicius A, Ranasinghe RT, Catalano M, Zhang X, et al. Single-molecule visualization of DNA G-quadruplex formation in live cells. Nat Chem.
Diagnostic performance of one visual aura image in identifying migraine with aura
BRIEF RESEARCH REPORT article Front. Neurol. Sec. Headache and Neurogenic Pain This article is part of the Research TopicAura and Sensory Phenomena Across Headache Disorders: Mechanisms, Comorbidities, and Therapeutic InnovationsView all articles Diagnostic performance of one visual aura image in identifying migraine with aura Provisionally accepted Leiden University Medical Center (LUMC), Leiden, Netherlands The final, formatted version of the article will be published soon.
[2508.09337] Decoding Neural Emotion Patterns through Large Language Model Embeddings
[Submitted on 12 Aug 2025 ( v1 ), last revised 11 Sep 2025 (this version, v2)] Title:Decoding Neural Emotion Patterns through Large Language Model Embeddings View a PDF of the paper titled Decoding Neural Emotion Patterns through Large Language Model Embeddings, by Gideon Vos and 4 other authors View PDF HTML (experimental) Abstract:Understanding how emotional expression in language relates to brain function is a challenge in computational neuroscience and affective computing.
[2504.16143] A Statistical Approach for Synthetic EEG Data Generation
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Acta neurologica belgica regarding the manuscript entitled ‘Safety and efficacy of extended versus standard interval dosing of natalizumab in multiple sclerosis patients: a systematic review and meta-analysis’ | Acta Neurologica Belgica
This is a preview of subscription content, to check access. Get 10 units per month Download Article/Chapter or eBook 1 Unit = 1 Article or 1 Chapter Cancel anytime Price excludes VAT (USA) Tax calculation will be finalised during checkout. Instant access to the full article PDF. Data availability No datasets were generated or analysed during the current study.
Rethinking phase 2 trials in amyotrophic lateral sclerosis
Clinical trials typically progress sequentially through early, mid and late stages, often referred to as phase 1, phase 2 and phase 3. Phase 2 trials, broadly speaking, aim to gather information about safety, tolerability and dosing of an experimental treatment, and to determine whether the therapeutic agent is sufficiently promising to warrant further investigation in a large-scale, randomized, controlled phase 3 study.
Menstrual cups to reduce bacterial vaginosis and STIs through reduced harmful sexual and menstrual practices among economically vulnerable women: protocol of a single arm trial in western Kenya | BMC Public Health | Full Text
This study seeks to evaluate the preliminary efficacy of menstrual cups that can be worn during sex on BV, non-optimal VMB, and STIs of women engaged in sex for livelihood in western Kenya, to assess the cups’ safety profile, and to understand implementation needs. This study hypothesizes that among women who rely on sex for livelihood, provision of menstrual cups that can be worn during sex will result in reduced occurrence of BV, non-optimal VMB, and STIs, independent of sexual practices.
Which heart failure patients benefit most from non-invasive telemedicine? An overview of current evidence and future directions - Netherlands Heart Journal
Abstract Telemedicine in heart failure (HF) management may positively impact health outcomes, but varied effects in studies hinder guidance in HF guidelines. Evidence on the effectiveness of telemedicine in HF subpopulations is limited. We conducted a scoping review to evaluate and synthesise evidence on the effectiveness of telemedicine across HF subpopulations that could guide telemedicine strategies in routine practice.
Towards a useful and cost-effective workup in chronic polyneuropathy: the EXPRESS study protocol
This content is only available via PDF. This work is licensed under a Creative Commons Attribution 4.0 International License .
Toward a Useful and Cost-Effective Workup in Chronic Polyneuropathy: The EXPRESS Study Protocol
Keywords: Polyneuropathy, Protocol, Diagnostics In the Netherlands, each year more than 13,000 patients are newly diagnosed with polyneuropathy, which has an estimated prevalence of up to 9.4% in the population aged 50 years and older [1‒3]. Some causes are common, such as diabetes, and others uncommon, such as hereditary or immune-mediated polyneuropathy.
Revisiting distinct nerve excitability patterns in patients with amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease, characterized by loss of central and peripheral motor neurones. Although the disease is clinically and genetically heterogeneous, axonal hyperexcitability is a commonly observed feature that has been suggested to reflect an early pathophysiological step linked to the neurodegenerative cascade.
Sociodemographic and psychosocial risk factors of railway suicide a mixed-methods study combining data of all suicide decedents in the Netherlands with data from a psychosocial autopsy study | BMC Public Health | Full Text
Between 2017 and 2021, 9241 individuals died by suicide in the Netherlands. Most decedents were male (n = 6235) and Dutch natives (n = 7524). As shown in Table 1 below, 986 individuals died by railway suicide. These were 686 males (70%) and 300 females (30%). Chi-squared analyses reported significant group differences between railway suicides compared to other methods of suicide.
[2402.04681] Architectural Design Decisions for Self-Serve Data Platforms in Data Meshes
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[2308.14776] Systematic reduction of Hyperspectral Images for high-throughput Plastic Characterization
[Submitted on 28 Aug 2023] Title:Systematic reduction of Hyperspectral Images for high-throughput Plastic Characterization Download a PDF of the paper titled Systematic reduction of Hyperspectral Images for high-throughput Plastic Characterization, by Mahdiyeh Ghaffari and 5 other authors Download PDF Abstract: Hyperspectral Imaging (HSI) combines microscopy and spectroscopy to assess the spatial distribution of spectroscopically active compounds in objects, and has diverse applications in...
Reflecting on four Living Labs in the Netherlands and Indonesia: a perspective on performance, public engagement and participation
1 Introduction With the increased incidence of phenomena such as heavy rainfall, thunderstorms, flooding’s, heatwaves and wildfires, a wider reconnaissance of the Anthropocene is discernible. The sustainable development goals (SDGs), indicate global recognition of contemporary challenges such as hunger, climate change, biodiversity losses, protracted conflicts and poverty, and thereby constitute a call for partnerships between diverse actors to act accordingly.
Longitudinal prospective cohort study to assess peripheral motor function with extensive electrophysiological techniques in patients with Spinal Muscular Atrophy (SMA): the SMA Motor Map protocol (pdf) | Paperity
BMC Neurology, Apr 2023 This is a preview of a remote PDF: https://bmcneurol.biomedcentral.com/counter/pdf/10.1186/s12883-023-03207-5 Ros, Leandra A. A., Goedee, H. Stephan, Franssen, Hessel, Asselman, Fay-Lynn, Bartels, Bart, Cuppen, Inge, van Eijk, Ruben P. A., Sleutjes, Boudewijn T. H. M., van der Pol, W. Ludo, Wadman, Renske I.. , BMC Neurology, 2023, pp. 1-10, Volume 23, Issue 1, DOI: 10.1186/s12883-023-03207-5
A latent class analysis using the integrated motivational-volitional model of suicidal behaviour: Understanding suicide risk over 36 months
van Eijk, N. L., Wetherall, K., Ferguson, E., O'Connor, D. and O'Connor, R. C. (2023) A latent class analysis using the integrated motivational-volitional model of suicidal behaviour: Understanding suicide risk over 36 months. Journal of Affective Disorders, (doi: 10.1016/j.jad.2023.05.028) (In Press) Text 298599.pdf - Accepted Version Restricted to Repository staff only until 15 May 2024.
Amino acid variation at VP1-145 of Enterovirus A71 determines the viral infectivity and receptor usage in a primary human intestinal model
Ikrame Aknouch1, 2, 3, 4*, Inés García-Rodríguez2, 3, Francesca Paola Giugliano5, Carlemi Calitz2, 3, Gerrit Koen2, Hetty Van Eijk2, Nina Johannessson2, 3, Sjoerd Rebers2, Lieke Brouwer2, 3, Vanesa Muncan5, Koert J. Stittelaar6, Dasja Pajkrt3, Katja C.
Use of hip- versus wrist-based actigraphy for assessing functional decline and disease progression in patients with motor neuron disease
Journal of Neurology, Feb 2023 This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007/s00415-023-11584-7.pdf Holdom, Cory J., van Unnik, Jordi W. J., van Eijk, Ruben P. A., van den Berg, Leonard H., Henderson, Robert D., Ngo, Shyuan T., Steyn, Frederik J.. , Journal of Neurology, 2023, pp. 1-9, DOI: 10.1007/s00415-023-11584-7
Healthy and Happy Citizens: The Opportunities and Challenges of Co-Producing Citizens’ Health and Well-Being in Vulnerable Neighborhoods
1. Introduction Healthcare systems in welfare states are increasingly facing major challenges (WHO 2018). Technological innovations, an ageing population, staff shortages and rising expenditures all represent significant challenges for contemporary welfare states (Rostgaard et al. 2016).
Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS - Nature Neuroscience
Abstract The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed region-based rare variant association analysis of >25,000 variants in untranslated regions of 6,139 amyotrophic lateral sclerosis (ALS) whole genomes and the whole genomes of 70,403 non-ALS controls.
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation - Nature Genetics
Abstract Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations.
Current trends in the clinical trial landscape for... : Current Opinion in Neurology
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