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Articles by Van Helden
IFB-ElixirFr/AI-bioscripting-workshop: AI scripting for bioanalysis workshop — 2025 session
Published June 11, 2026 | Version v2025.2 Software Open Teaching material and practical session for the 2025 edition of the workshop "Utilisation des IA génératives comme appui à la programmation et au scripting pour la biologie". Renamed the git repository AI-bioscripting-workshop Release for zenodo archive. Software: https://github.com/IFB-ElixirFr/AI-bioscripting-workshop/tree/v2025.2 (URL)
EVALUATING LOCATIONS FOR SEASONAL THERMAL ENERGY STORAGES
Published April 21, 2026 | Version v1 Poster Open This poster evaluates optimal siting strategies for seasonal thermal energy storage (STES), comparing central and remote locations. It shows that while remote sites can reduce heat losses, these benefits are often offset by higher electricity use and infrastructure costs.
Types of Large Thermal Energy Storages and Introduction to the TREASURE project
Published April 9, 2026 | Version v1 Presentation Open 1. AEE Institute for Sustainable Technologies This presentation provides an overview of key storage technologies (ATES, BTES, CTES, MTES, PTES, TTES) and their role in future district heating systems. It also introduces the TREASURE project, which aims to accelerate the deployment of pit thermal energy storage through demonstrations, simulations, and knowledge sharing.
Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases: results from a randomized trial in ovarian cancer
Current standard treatment for advanced epithelial ovarian cancer (OC) comprises cytoreductive surgery (CRS) and systemic therapy. Despite initially successful treatment, up to 80% of patients develop recurrent peritoneal disease1. Combining interval CRS with hyperthermic intraperitoneal chemoperfusion (HIPEC) has been shown to lower the risk of peritoneal recurrence2.
The effects of insecticide seed treatments on the parasitism and predation of Myzus persicae (Homoptera: Aphididae) in canola
The green peach aphid, Myzus persicae (Sulzer) (Homoptera: Aphididae), is a major pest of brassica plants, with the ability to transmit > 100 viruses. Although the adoption of Integrated Pest Management is increasing, chemical treatment remains the predominant method used to control M. persicae globally.
FAIR+E pathogen data for surveillance and research: lessons from COVID-19
Introduction High-throughput Sequencing (HTS) has made a huge impact in medicine, and pushed us into the era of personalized and genomic medicine. Microbiology is one of the fields where an unprecedented revolution has taken place, as HTS allows genomic characterization of pathogens of interest at clinical and public health levels, which eases their surveillance and outbreak control, making the concept of One Health (1, 2) a reality.
Radiographic Predictors of Conversion to Total Knee Arthropl... : JBJS
Scientific Articles Results in a Large Multicenter Cohort The Journal of Bone and Joint Surgery | DOI: 10.2106/JBJS.22.00500 The main goals of surgery for a tibial plateau fracture are to reestablish joint stability, achieve normal limb alignment, and restore the articular surface1,2. Achieving these surgical goals reduces the risk of posttraumatic osteoarthritis and the subsequent need for total knee arthroplasty (TKA)3.
JBJS
Radiographic Predictors of Conversion to Total Knee Arthroplasty After Tibial Plateau Fracture Surgery Results in a Large Multicenter Cohort Background: Radiographic measurements of initial displacement of tibial plateau fractures and of postoperative reduction are used to determine treatment strategy and prognosis. We assessed the association between radiographic measurements and the risk of conversion to total knee arthroplasty (TKA) at the time of follow-up.
Frontiers | The localised density of H 2 O 2 in the effluent of a cold atmospheric pressure plasma jet determined by continuous-wave cavity ring-down spectroscopy
Sarah-Johanna Klose1*, Levin Kroes1 and Jean-Pierre H. van Helden1 1Leibniz Institute for Plasma Research and Technology e.V. (INP), Germany The final, formatted version of the article will be published soon.
“Spotting” Mycobacterium bovis infection in leopards (Panthera pardus) - novel application of diagnostic tools
1 Introduction Leopards (Panthera pardus) occupy diverse habitats across Africa and Asia, but are listed as vulnerable, with some populations decreasing (1). These iconic species play a role in terrestrial ecosystem functions, biodiversity maintenance, ecotourism industries, and cultural rituals in some South African societies (2, 3). However, apex predators including leopards are threatened by ecological disturbances, climate change, and infectious diseases (4, 5).
Modulating the microenvironment during FVIII uptake influences the nature of FVIII-peptides presented by antigen-presenting cells
Introduction Hemophilia A is a congenital bleeding disorder characterized by the lack or insufficient amount of functional factor VIII (FVIII) in the circulation which results in prolonged bleeding episodes due to ineffective blood coagulation upon injury (1). Most patients with severe hemophilia A receive FVIII replacement therapies (2).
Comment of a critical review about the origins of SARS-CoV-2
October 31, 2021 Journal article Open Access Graner, François; Courtier-Orgogozo, Virginie; Decroly, Etienne; Butler, Colin D.; Ebright, Richard H.; Colombo, Fabien; Kaina, Bernd; Rahalkar, Monali C.; Halloy, José; Bahulikar, Rahul A.; Theißen, Günter; Leitenberg, Milton; Morand, Serge; Kakeya, Hideki; Claverie, Jean-Michel; van Helden, Jacques This manuscript was submitted as a “Letter to the Editor” to Cell on October 31, 2021, to address some issues with the article "The origins of...
Something more than imagination: archaeology and fiction
Witcher, R.E. and van Helden, D.P. (2021) 'Something more than imagination: archaeology and fiction.', in Writing remains: new intersections of archaeology, literature and science. , pp. 177-201.
A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes
Abstract The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvirus affected the subsequent development of allergic asthma. We found that murid herpesvirus 4 (MuHV-4) inhibited the development of house dust mite (HDM)-induced experimental asthma by modulating lung innate immune cells.
Review article: lymphatic system and associated adipose tissue in the development of inflammatory bowel disease
Summary Background The lymphatic system plays critical roles in tissue fluid homoeostasis, immune defence and metabolic maintenance. Lymphatic vessels transport lymph, proteins, immune cells and digested lipids, allowing fluid and proteins to be returned to the blood stream, lipids to be stored and metabolized and antigens to be sampled in lymph nodes.
Minimum Information about an Uncultivated Virus Genome (MIUViG)
1. Breitbart, M., Bonnain, C., Malki, K. & Sawaya, N.A. Phage puppet masters of the marine microbial realm. Nat. Microbiol. 3, 754–766 (2018). 2. Youle, M., Haynes, M. & Rohwer, F. in Viruses: Essential Agents of Life (ed. Witzany, G.) 61–81 (Springer Netherlands, 2012). 3. Brum, J.R. & Sullivan, M.B. Rising to the challenge: accelerated pace of discovery transforms marine virology. Nat. Rev. Microbiol. 13, 147–159 (2015). 4. Páez-Espino, D. et al. Uncovering Earth's virome. Nature 536, 425–430 (2016). 5. Shi, M.
AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses
Subjects: Immunobiology and Immunotherapy, Myeloid Neoplasia, Transplantation Topics: antibodies, leukemia, tissue transplants Subjects: Immunobiology and Immunotherapy, Myeloid Neoplasia, Transplantation Topics: antibodies, leukemia, tissue transplants Subjects: Immunobiology and Immunotherapy, Myeloid Neoplasia, Transplantation Topics: antibodies, leukemia, tissue transplants Allogeneic hematopoietic stem-cell transplantation (HSCT) is an established form of immunotherapy that is often...
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