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Articles by van Nifterick
Local signal variability and functional connectivity: Sensitive measures of the excitation-inhibition ratio?
Cognitive Neurodynamics, Sep 2023 A novel network version of permutation entropy, the inverted joint permutation entropy (JPEinv), holds potential as non-invasive biomarker of abnormal excitation-inhibition (E-I) ratio in Alzheimer’s disease (AD). In this computational modelling study, we test the hypotheses that this metric, and related measures of signal variability and functional connectivity, are sensitive to altered E-I ratios.
Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes
Alzheimer's Research & Therapy, Aug 2023 Studies in animal models of Alzheimer’s disease (AD) have provided valuable insights into the molecular and cellular processes underlying neuronal network dysfunction. Whether and how AD-related neurophysiological alterations translate between mice and humans remains however uncertain. We characterized neurophysiological alterations in mice and humans carrying AD mutations in the APP and/or PSEN1 genes, focusing on early pre-symptomatic changes.
Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes - Alzheimer's Research & Therapy
Male APP/PS1-PV-Cre mice (a cross of APP/PS1 and PV-Cre mice) were used. APP/PS1 mice [The Jackson Laboratory; strain B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J with stock number 004462] are double-transgenic mice that harbor a chimeric human/mouse APP gene (Mo/HuAPP695swe) as well as a mutant human PSEN1 gene with a deletion of exon 9 (PS1dE9) [39]. Both transgenes are controlled by the mouse prion protein promoter.
Tau protein spreads through functionally connected neurons in Alzheimer’s disease: a combined MEG/PET study
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Tau protein spreads through functionally connected neurons in Alzheimer’s disease: a combined MEG/PET study
When you visit web sites, they may store or retrieve data in your web browser. This storage is often necessary for basic functionality of the web site or the storage may be used for the purposes of marketing, analytics, and personalization of the web site such as storing your preferences.
Network Hyperexcitability in Early Alzheimer’s Disease: Is Functional Connectivity a Potential Biomarker?
Brain Topography, May 2023 This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007/s10548-023-00968-7.pdf Stam, C. J., van Nifterick, A. M., de Haan, W., Gouw, A. A.. , Brain Topography, 2023, pp. 1-18, DOI: 10.1007/s10548-023-00968-7
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