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Articles by Van Osch
Cerebral “Dirty-Appearing” White Matter in Relation to Cognitive Decline and Dementia Risk in Community-Dwelling Older Adults
Research Article Open AccessNull Hypothesis Introduction Cerebral small vessel disease (cSVD) in older adults is a major contributor to cognitive decline and dementia, also in adults with Alzheimer disease.1-4 Early cSVD markers are urgently needed to allow for selection of individuals for preventative treatment such as lifestyle interventions or for future treatment trials aimed at prevention of cognitive decline and dementia.
In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy
Research Article Open Accesseditorial Introduction Cerebral amyloid angiopathy (CAA) is neuropathologically defined by the deposition of β-amyloid (Aβ) in the walls of leptomeningeal vessels and small arteries, arterioles, and capillaries in the cortex.1 Clinically, CAA is a leading cause of lobar intracerebral hemorrhage (ICH), which is associated with high mortality rates and disability.2 Although an overall pathophysiologic framework has recently been proposed, the precise mechanisms that...
Renal cell carcinoma detection: a systematic review in diagnostic urinary biomarkers - BMC Cancer
This systematic review summarized available evidence on urinary diagnostic biomarkers for RCC including metabolites (n = 40), proteins (n = 29), miRNAs (n = 12), DNA methylation markers (n = 13) and others (n = 11). Additionally, 29 panels combining several biomarkers were identified and in general, these panels outperformed individual biomarkers.
Diagnosis extraction from unstructured Dutch echocardiogram reports using span- and document-level characteristic classification - BMC Medical Informatics and Decision Making
Abstract Clinical machine learning research and artificial intelligence driven clinical decision support models rely on clinically accurate labels. Manually extracting these labels with the help of clinical specialists is often time-consuming and expensive. This study tests the feasibility of automatic span- and document-level diagnosis extraction from unstructured Dutch echocardiogram reports.
[2409.13477] A Plug-and-Play Method for Guided Multi-contrast MRI Reconstruction based on Content/Style Modeling
[Submitted on 20 Sep 2024] Title:A Plug-and-Play Method for Guided Multi-contrast MRI Reconstruction based on Content/Style Modeling View a PDF of the paper titled A Plug-and-Play Method for Guided Multi-contrast MRI Reconstruction based on Content/Style Modeling, by Chinmay Rao and 9 other authors View PDF HTML (experimental) Abstract:Since multiple MRI contrasts of the same anatomy contain redundant information, one contrast can be used as a prior for guiding the reconstruction of an...
One size does not fit all: micro- meso and macrobleeds in cerebral amyloid angiopathy
Journal Section: Imaging This content is only available via PDF. This work is licensed under a Creative Commons Attribution 4.0 International License .
[2408.06930] Diagnosis extraction from unstructured Dutch echocardiogram reports using span- and document-level characteristic classification
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Electronic cigarette social norms among adolescents in New South Wales, Australia
In Australia, 30% of 12- to 17-year-olds reported ever having used electronic cigarettes (e-cigarettes) in 2022/2023, a >50% increase from 2017 (14%) (Scully et al., 2023). A sample of 14- to 17-year-olds living in New South Wales, Australia’s most populous state, found that 32% had ever used e-cigarettes in 2021 (Watts et al., 2022). These high prevalences of use are in spite of laws preventing the sale or supply of e-cigarettes under 18-year-olds.
The relation between vascular risk factors and flow in cerebral perforating arteries. A 7 Tesla MRI study.
Journal Section: Imaging This content is only available via PDF. This work is licensed under a Creative Commons Attribution 4.0 International License .
A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy
Maintenance of cerebral homeostasis not only requires constant blood supply but also continuous elimination of waste products from the brain.
Hypothetical Interventions on Diet Quality and Lifestyle Factors to Improve Breast Cancer Survival: The Pathways Study
Excluding skin cancers, breast cancer is the most commonly-diagnosed cancer among woman globally (1). However, female breast cancer survivors are now living longer than ever, and there are currently over 3.8 million survivors in the United States (2). These women are highly motivated to make lifestyle changes, and desire more evidence-based information from health professionals (3–5).
Sulforaphane as a potential modifier of calorie-induced inflammation: a double-blind, placebo-controlled, crossover trial
1 Introduction Non-communicable diseases (NCDs) are the leading cause of death worldwide, accounting for 71% of total deaths each year (1). Chronic low-grade inflammation (CLGI) plays a crucial role in the pathology of NCDs, but also appears to affect apparently healthy people as a consequence of poor lifestyle choices, e.g., overeating, smoking and excessive alcohol consumption (2–4).
Senescence during early differentiation reduced the chondrogenic differentiation capacity of mesenchymal progenitor cells
Chantal Voskamp1 Wendy J. L. M. Koevoet2 Gerjo J. V. M.
Minocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): study protocol for a placebo-controlled randomized double-blind trial - Trials
Study design This is an exploratory study. Our study design is a randomized double-blind placebo-controlled trial with minocycline treatment versus placebo for 3 months in 60 participants (30 with D-CAA and 30 with sporadic CAA). At baseline (t = 0), a standardized neuropsychological assessment will be performed (Fig. 1).
Frontiers | Adjective position in the code-switched speech of Spanish and Papiamento heritage speakers in the Netherlands: Individual differences and methodological considerations
Brechje van Osch1*†, M.
New model of superior semicircular canal dehiscence with reversible diagnostic findings characteristic of patients with the disorder
Introduction While it was nearly a century ago that Tullio described the physiologic outcomes of creating a third mobile window in the semicircular canals of pigeons (1, 2), it was a quarter century ago that Minor et al. first described superior semicircular canal dehiscence (SSCD) in two patients (3). However, this is not a new clinical entity as SSCD has been observed after CT imaging of Egyptian mummy heads (4).
Frontiers | Adjective Position in the code-switched speech of Spanish and Papiamento heritage speakers in the Netherlands: Individual differences and methodological considerations
Brechje Van Osch1*, Maria del Carmen Parafita Couto2, 3, Ivo Boers3, 4 and Bo Sterken5 1UiT The Arctic University of Norway, Norway 2Leiden University, Netherlands 3University of Vigo, Spain 4Károli Gáspár University of the Reformed Church in Hungary, Hungary 5University of Groningen, Netherlands The final, formatted version of the article will be published soon.
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