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This study protocol is reported following the 2013 Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline. See Appendix 1 for the SPIRIT checklist [24]. Study design The PREOPANC-4 training phase started in 2021 after which the 3-year implementation will take place from January 2022 until December 2024, followed by a follow-up of 5 years until December 2029.
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