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Articles by van Tellingen
Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production Open Access
Citation Remco Nagel, Adva Kochavi, Karine Flem-Karlsen, Mrittika Adhikary, Yali Gal-On, Maria G. Klaoudatou, Julien Champagne, Lorenzo Valcanover, Heyilimu Palashati, Morten M. Nielsen, Xiaodong Feng, Pierre-Rene Körner, Lisanne Giebel, Weiwen Yang, Arno Velds, Liesbeth Hoekman, Onno B. Bleijerveld, Olaf van Tellingen, Johanna Olweus, Reuven Agami; Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production.
Computer Science > Computation and Language
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Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production Open Access
Open figure viewer This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License .
C-terminal Truncation and Fusion Partner Determine Oncogenicity of FGFR3
Genomic alterations affecting components of the fibroblast growth factor (FGF) signaling axis can trigger aberrant pathway activation and tumor development. Genomic truncation of the FGF receptor 2 (FGFR2) exon 18 (E18) disrupts the FGFR2 carboxy-terminal tail (C-tail), acting as a potent driver alteration across multiple tumor types. Here, we analyzed human oncogenomic datasets to reveal that E18 truncations are similarly prevalent in FGFR3, an FGFR2 paralog.
Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients - Molecular Cancer
Doxorubicin and etoposide were purchased from Pharmachemie (The Netherlands), daunorubicin was obtained from Sanofi-Aventis and epirubicin was obtained from Accord Healthcare Limited (UK), idarubicin was obtained from Pfizer and Santa Cruz Biotechnology (sc-204774). Aclarubicin for in vivo mouse experiments was obtained from Shenzhen Main Luck Pharmaceuticals Inc. Aclarubicin (for in vitro experiments, sc-200160) and amrubicin (sc-207289) were obtained from Santa Cruz Biotechnology. K562 (B.
Non-therapeutic plasma levels in individuals utilizing curcumin supplements in daily life
1 Introduction The spice curcumin originates from the root of the Curcuma Longa plant and has been used for centuries in Asian cultures as dietary pigment, spice and traditional medicine. Curcumin has been associated with many beneficial health outcomes, such as anti-inflammatory and anti-cancer effects (1–3). However, these effects have mostly been assessed in in vitro experiments.
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants - Nature
Abstract Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1,2,3,4. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons. We identified tryptophan-to-phenylalanine codon reassignment (W>F) as the major event facilitating this process, and pinpointed tryptophanyl-tRNA synthetase (WARS1) as its source.
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