Keywords Metyrapone Adrenal adenoma Adrenal mass Treatment Circadian Subclinical hypercortisolism Evidence before this study We searched PubMed for studies published between January 1, 2000, and February 21, 2026, using the terms “metyrapone” and “mild autonomous cortisol secretion”, “autonomous cortisol secretion”, or “subclinical Cushing”. The evidence base for metyrapone in mild autonomous cortisol secretion (MACS) was limited and consisted of small mechanistic and clinical studies.
