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Citation Martin K. Bakht, Jacob Egelberg, Yasutaka Yamada, Louise Clark, Xiao Wei, Varadha Balaji Venkadakrishnan, Anthony P. Belanger, Alice Bernard-Tessier, Sarah J. Hill, Francesca Khani, David J. Einstein, Mary-Ellen Taplin, Eliezer Van Allen, Heather A. Jacene, Himisha Beltran; Abstract PR027: Spatial heterogeneity atlas of prostate cancer evolution (SHAPE): Spatial and genomic landscapes of advanced prostate cancer with and without Lu-PSMA therapy.
Citation Richa Singh, Varadha Balaji. Venkadakrishnan, Eddie Imada, Yasutaka Yamada, Nicholas J. Brady, Kate Dunmore, Richard Garner, Brian D. Robinson, David S. Rickman, Himisha Beltran; Abstract PR035: Cooperativity between DNA methylation and EZH2 activity drives neuroendocrine phenotype in advanced prostate cancer. Cancer Res 15 January 2026; 86 (2_Supplement): PR035. https://doi.org/10.1158/1538-7445.PROSTATECA26-PR035 Download citation file:
Prostate cancer (PCa) remains the second leading cause of cancer death in men in Western cultures. Deeper understanding of the mechanisms by which PCa cells divide to support tumor growth could help devise strategies to overcome treatment resistance and improve survival. Here, we identified that the mitotic AGC family protein kinase citron kinase (CIT) is a pivotal regulator of PCa growth which mediates PCa cell interphase progression.
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