Inflammatory diseases linked to bone destruction such as RA and periodontitis are associated with local neutrophil infiltration in disease lesions (Cascao et al., 2010; Landzberg et al., 2015). While neutrophils have been implicated in these conditions, their role in mediating inflammatory bone destruction has not been fully determined. Here, we demonstrate a causative link between NETs and inflammatory bone destruction in vivo in a well-established model of periodontitis.
