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ADV adenovirus DFU diabetic foot ulcer HIF-1 hypoxia-inducible factor-1 MC minicircle PIGF placenta growth factor PLGA poly (lactic-co-glycolic acid) PDLLA poly (d,l-lactide) rhVEGF recombinant human VEGF VEGF vascular endothelial growth factor vp viral particles 1 INTRODUCTION Diabetes mellitus (DM) is a well-known and increasing challenge in the Western healthcare system, leading to a likewise increase in complications.
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