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Abstract Netrin‑1, a secreted protein initially characterized for its role in axon guidance, has emerged as a critical mediator of cancer progression. Preclinical studies with the anti‑netrin‑1 antibody NP137, which blocks the netrin‑1–UNC5B interaction, have demonstrated reactivation of tumor suppressor functions and sensitization of cancer cells to chemotherapy.
The G-protein-coupled Y4-receptor (Y4R) and its endogenous ligand, pancreatic polypeptide (PP), suppress appetite in response to food intake and, thus, are attractive drug targets for body-weight control. The C-terminus of human PP (hPP), T32-R33-P34-R35-Y36-NH2, penetrates deep into the binding pocket with its tyrosine-amide and di-arginine motif.
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