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Heart failure (HF) is defined as the inability of the heart to meet the oxygen demand of metabolizing tissues.1 HF with reduced left ventricular ejection fraction (HFrEF) is primarily defined by a decrease in left ventricular (LV) systolic function, although concomitant diastolic dysfunction is common. The atrial contribution to LV filling is ?35%.2 The early stages of HF show an increased atrial response with increased reservoir and pump function.
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