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Articles by Victor S. Ndaw
TGF-β1 Suppresses IL-33-Induced Mast Cell Function
TGF-?1 Suppresses IL-33–Induced Mast Cell Function Victor S. Ndaw, Daniel Abebayehu, Andrew J. Spence, Patrick A. Paez, E. Motunrayo Kolawole, Marcela T. Taruselli, Heather L. Caslin, Alena P. Chumanevich, Anuya Paranjape, Bianca Baker, Brian O. Barnstein, Tamara T. Haque, Kasalina N. Kiwanuka, Carole A. Oskeritzian, John J. Ryan The Journal of Immunology August 1, 2017, 199 (3) 866-873; DOI: 10.4049/jimmunol.1601983
TGF-β1 Suppresses IL-33-Induced Mast Cell Function
TGF-?1 Suppresses IL-33–Induced Mast Cell Function Victor S. Ndaw, Daniel Abebayehu, Andrew J. Spence, Patrick A. Paez, E. Motunrayo Kolawole, Marcela T. Taruselli, Heather L. Caslin, Alena P. Chumanevich, Anuya Paranjape, Bianca Baker, Brian O. Barnstein, Tamara T. Haque, Kasalina N. Kiwanuka, Carole A. Oskeritzian, John J. Ryan The Journal of Immunology June 21, 2017, ji1601983; DOI: 10.4049/jimmunol.1601983
TGFβ inhibits IL-33-mediated mast cell activation in vitro and in vivo
TGFβ is involved in many pathological conditions, including autoimmune disorders, cancer, and cardiovascular and allergic diseases. We have previously found that TGFβ suppresses IgE-mediated mast cell activation in human and mouse mast cells in vitro. IL-33 is a recently discovered member of the IL-1 family that functions as an “alarmin” stimulating mast cell responses and enhancing IgE-mediated activation. How TGFβ affects IL-33 signaling is now known.
Fluvastatin induces mast cell apoptosis and autophagy: effects on primary and transformed mast cells
Mast cells are best known for their role in inflammatory and allergic disease. Mast cell leukemia is a rare subtype of acute myelogenous leukemia, most of which express the c-Kit mutation, D816V, that yields factor-independent growth. Understanding and treating mast cell hyperplasia and leukemia could be beneficial to both inflammatory and malignant diseases.
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