Age-related neurodegenerative diseases are a major cause of disability and mortality in older adults, and Lewy body disease (LBD) is among the most important and clinically heterogeneous of these disorders.1, 2 Defined by abnormal neuronal α-synuclein aggregation, LBD underlies Parkinson's disease (PD), dementia with Lewy bodies, idiopathic rapid eye movement (REM) sleep behavior disorder, and a substantial proportion of mixed neurodegenerative and dementia syndromes.1, 3, 4 Yet despite its...
