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von Mering

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Articles by von Mering

Study of microbiome development and coalescence in soil microcosms using taxa-diverse communities of distinct origin.

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By von Mering, van der Meer, Jan Roelof
| zenodo.org
The files stored here contain the data and code for manuscript in submission: Habitat filtering but not microbiota origin controls microbiome transplant outcomes in soil. Senka Causevic1,  Janko Tackmann2,  Vladimir Sentchilo1,  Lukas Malfertheiner2,  Christian von Mering2,  Jan Roelof van der Meer1 1) Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland 2) Department of Molecular Life Sciences, University of Zurich, 8006 Zurich, Switzerland
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Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs

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By Georg E. Winter, Lars Juhl, von Mering, Ian E. D
| dx.doi.org
Introduction Click to copy section linkSection link copied! Small molecules play a pivotal role as chemical probes, facilitating the dose- and time-dependent modulation of protein function to shed light on biological mechanisms. Throughout history, small molecules have also formed the cornerstone of many pharmaceutical treatments for human diseases. Despite the rising interest in biologics or cell-based therapies, most FDA-approved drugs are small-molecules.
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Limits to robustness and reproducibility in the demarcation of operational taxonomic units

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By Christian von Mering, von Mering, Matias Rodrigues
| Wiley
Summary The demarcation of operational taxonomic units (OTUs) from complex sequence data sets is a key step in contemporary studies of microbial ecology. However, as biologically motivated ‘optimal’ OTU‐binning algorithms remain elusive, many conceptually distinct approaches continue to be used. Using a global data set of 887 870 bacterial 16S rRNA gene sequences, we objectively quantified biases introduced by several widely employed sequence clustering algorithms.
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A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes

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By Bas E Dutilh, van Noort, von Mering, Noriko Cassman
| Nature Verified
Metagenomes, and especially viral metagenomes, are often characterized by a majority of unknown sequences that have no homologues in the database21. Assembly of the short, second generation sequencing reads into longer contigs may facilitate their annotation and interpretation.
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