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Earlier diagnosis through screening mammography, improved loco-regional treatment modalities and a broader use of effective adjuvant systemic therapies in the form of chemotherapy and/or targeted therapies have all contributed to a significant decline in breast cancer (BC) mortality in the Western world. , 2 EBCTCG: Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15 year survival: an overview of the randomized trials.
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