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Articles by Wei Sang
Impact of IL-6 and ferritin dynamics on clinical outcomes after anti-CD19 CAR-T cell therapy in diffuse large B-cell lymphoma patients
Abstract Background: Interleukin-6 (IL-6) and ferritin are routinely monitored during chimeric antigen receptor T-cell (CAR-T) therapy; however, their temporal dynamics and outcome-specific relevance remain inadequately characterized. This study aimed to evaluate the value of IL-6 and ferritin at multiple time points in patients with diffuse large B-cell lymphoma (DLBCL) receiving anti-CD19 CAR-T therapy.
Deformation behaviour of over–consolidated soil in a deep confined aquifer under multi–stage pore pressure changes in Shanghai, China
Abstract Shanghai, a typical coastal soft–soil area, is characterised by thick soft layers with high compressibility and low permeability. Together with five confined aquifers, these layers form a complex multi–aquifer system. Historically, excessive deep groundwater extraction caused severe land subsidence.
Correction to “Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy”
Journal of the American Chemical Society Cite this: J. Am. Chem. Soc. 2025, XXXX, XXX Click to copy citationCitation copied! . This publication is available under these Terms of Use. Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial - Nature Communications
Abstract Despite the high therapeutic response achieved with B-cell maturation antigen (BCMA)-specific chimeric antigen receptor (CAR) T-cell therapy in relapsed and refractory multiple myeloma (R/R MM), primary resistance and relapse exist with single-target immunotherapy. Here, we design bispecific BC19 CAR T cells targeting BCMA/CD19 and evaluate antimyeloma activity in vitro and in vivo.
Advanced Metallized Nanofibers for Biomedical Applications
Abstract Nanofibers are long, wire-like materials with nanoscale diameters and specific length diameter ratios. Nanofibers have porous reticular networks with remarkably high specific surface areas and significant interconnectivity between pores, allowing for the chemical modification and loading of drugs.
The evolution of minimal residual disease: key insights based on a bibliometric visualization analysis from 2002 to 2022
Zhengyu Yu1†, Li Xie2†, Jing Zhang2, Hua Lin2* and Ting Niu1* 1Department of Hematology, West China Hospital, Sichuan University, Chengdu, China 2State Key Laboratory of Wildlife Quarantine and Surveillance (Sichuan), Technology Center of Chengdu Customs, Chengdu, China Background: The topic of minimal residual disease (MRD) has emerged as a crucial subject matter in the domain of oncology in recent years.
Active control of circular dichroism in a graphene-metal hybridized metamaterial driven by symmetry-protected bound states in the continuum
Active control of circular dichroism in a graphene–metal hybridized metamaterial driven by symmetry-protected bound states in the continuum Active control of chirality in plasmonic metamaterials is of great importance due to their potential for diverse applications in imaging, communication and spectroscopy. Recently, inspired by the concept of bound states in the continuum (BIC), strong chiroptical responses are constructed in metamaterials by introducing structural asymmetries.
RESEARCH ARTICLE Ming Shi, Ming Shi Jiangsu Center for the Collaboration and Innovation of Cancer Biotheraty, Cancer Institute, Xuzhou Medical University, Xuzhou, China These authors contributed equally to this work. Search for more papers by this author Li Li, Li Li Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China These authors contributed equally to this work.
A Metal‐Phenolic Nanosensitizer Performs Hydrogen Sulfide‐Reprogrammed Oxygen Metabolism for Cancer Radiotherapy Intensification and Immunogenicity
Research Article Jie Li, Jie Li University of Macau, Faculty of Health Sciences, MACAU Search for more papers by this author Lisi Xie, Lisi Xie University of Macau, Faculty of Health Sciences, MACAU Search for more papers by this author Wei Sang, Wei Sang University of Macau, Faculty of Health Sciences, MACAU Search for more papers by this author Wenxi Li, Wenxi Li University of Macau, Faculty of Health Sciences, MACAU Search for more papers by this author Guohao Wang, Guohao Wang University...
A Triple‐Kill Strategy for Tumor Eradication Reinforced by Metal‐Phenolic Network Nanopumps
Research Article Wei Sang, Wei Sang Cancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078 China MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, 999078 China Search for more papers by this author Zhan Zhang, Zhan Zhang Cancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078 China MoE Frontiers Science Center for Precision...
Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc.
A metal-polyphenolic nanosystem with NIR-II fluorescence-guided combined photothermal therapy and radiotherapy
A metal–polyphenolic nanosystem with NIR-II fluorescence-guided combined photothermal therapy and radiotherapy† Jie Li,‡ab Wenxi Li,‡ab Lisi Xie,ab Wei Sang,ab Guohao Wang,ab Zhan Zhang,ab Bei Li,ab Hao Tian,ab Jie Yan,ab Ye Tian,ab Zhenhua Li, c Quli Fan, d Lin Yu e and Yunlu Dai *ab Author affiliations * Corresponding authors a Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China E-mail: yldai@um.edu.mo b MoE...
Expression of YAP1 and pSTAT3-S727 and their prognostic value in glioma
Expression of YAP1 and pSTAT3-S727 and their prognostic value in glioma http://orcid.org/0000-0002-3512-7154Wei Sang, Jing Xue, Li-Ping Su, Abulajiang Gulinar, Qian Wang, Yang-Yang Zhai, Yan-Ran Hu, Hai-Xia Gao, http://orcid.org/0000-0002-0742-8072Xinxia Li, Qiao-Xing Li, Wei Zhang Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China Correspondence to Professor Wei Zhang, Department of Pathology, The First Affiliated Hospital of...
A practical and sustainable protocol for direct amidation of unactivated esters under transition-metal-free and solvent-free conditions
A practical and sustainable protocol for direct amidation of unactivated esters under transition-metal-free and solvent-free conditions In this paper, a NaOtBu-mediated synthetic approach was developed for direct amidation of unactivated esters with amines under transition-metal-free and solvent-free conditions, affording a series of amides in good to excellent yield at room temperature.
Polyphenol‐Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment
Research Article PDF ShareShare Abstract Engineering multifunctional nanoplatforms with high therapeutic benefits has become a promising strategy for intractable cancer treatment. A novel polyphenol‐based nanocomplex was designed to evoke highly efficacious cancer immunosurveillance while localizing therapy on the primary tumor and to minimize systemic side effects.
Expression of YAP1 and pSTAT3-S727 and their prognostic value in glioma
Expression of YAP1 and pSTAT3-S727 and their prognostic value in glioma http://orcid.org/0000-0002-3512-7154Wei Sang, Jing Xue, Li-Ping Su, Abulajiang Gulinar, Qian Wang, Yang-Yang Zhai, Yan-Ran Hu, Hai-Xia Gao, http://orcid.org/0000-0002-0742-8072Xinxia Li, Qiao-Xing Li, Wei Zhang Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China Correspondence to Professor Wei Zhang, Department of Pathology, The First Affiliated Hospital of...
Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy
Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy Jingjing Wang, Wei Sang, Zhen Yang, Zheyu Shen, Zhantong Wang, Orit Jacobson, Yundai Chen, Yong Wang, Mingyan Shao, Gang Niu, Yunlu Dai and Xiaoyuan Shawn Chen Abstract Combination therapy with multiple chemotherapeutic agents is the main approach for cancer treatment in clinic.
Recent advances in nanomaterial-based synergistic combination cancer immunotherapy
Recent advances in nanomaterial-based synergistic combination cancer immunotherapy Wei Sang,ab Zhan Zhang,ab Yunlu Dai*ab and Xiaoyuan Chen*c Author affiliations * Corresponding authors a Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China E-mail: yldai@um.edu.mo b Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China c Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical...
Electro‐Controlled Living Cationic Polymerization
Cationic polymerizations have long been industrialized; however, stimulus‐regulated cationic polymerization remains to be developed. An electrochemically controlled living cationic polymerization is presented for the first time. In the presence of external potential and organic‐based electrocatalyst, a series of monomers can be polymerized under a cationic chain‐transfer mechanism. The resulting polymers exhibit well‐defined molecular mass, narrow dispersity, and good chain‐end fidelity.
Electro‐Controlled Living Cationic Polymerization
Cationic polymerizations have long been industrialized; however, stimulus‐regulated cationic polymerization remains to be developed. An electrochemically controlled living cationic polymerization is presented for the first time. In the presence of external potential and organic‐based electrocatalyst, a series of monomers can be polymerized under a cationic chain‐transfer mechanism. The resulting polymers exhibit well‐defined molecular mass, narrow dispersity, and good chain‐end fidelity.
Electro-Controlled Living Cationic Polymerization
Cationic polymerizations have long been industrialized; however, stimulus-regulated cationic polymerization remains to be developed. Here we report an electrochemically controlled living cationic polymerization for the first time. In the presence of external potential and organic-based electrocatalyst, a series of monomers can be polymerized under a cationic chain transfer mechanism. The resulting polymers exhibit well-defined molecular mass, narrow dispersity and good chain-end fidelity.
H2S gasotransmitter-responsive polymer vesicles
Building biomimetic polymer vesicles that can sense a biological signaling molecule is a tremendous challenge at the cross-frontier of chemistry and biology. We develop a new class of o-azidomethylbenzoate (AzMB)-containing block copolymer that can respond to an endogenous signaling molecule, hydrogen sulfide (H S).
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