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Abstract The ovary is among the earliest organs to show clinically consequential age-related decline. The luteinizing hormone/choriogonadotropin receptor (LHCGR) mediates the trophic actions of LH and human chorionic gonadotropin (hCG) in the ovary, and reduced receptor abundance has sometimes been invoked as a possible explanation for age-related loss of LH responsiveness.
Abstract Objective: The optimal timing of surgery after conversion therapy for initially unresectable hepatocellular carcinoma (uHCC) remains unclear. This study aimed to evaluate whether surgical timing can be optimized by integrating major pathological response (MPR), defined as residual viable tumor (RVT) ≤15%, with preoperative treatment duration.
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