Abstract The long noncoding RNA AFAP1-AS1 is aberrantly expressed in multiple solid tumors, but its functional role in hepatocellular carcinoma (HCC) remains incompletely characterized. In this study, analysis of the TCGA-LIHC cohort and eight paired HCC and matched adjacent non-tumor tissues showed that AFAP1-AS1 was upregulated in HCC and associated with poorer overall survival in the TCGA cohort. Knockdown of AFAP1-AS1 inhibited the proliferation, migration, and invasion of HCC cells.
