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Highlights 1. Tacrolimus increased proteinuria remission in patients with IgA nephropathy 2. Tacrolimus-based treatment resulted in a higher remission rate than non-tacrolimus treatment 3. Tacrolimus did not increase the incidence of adverse events 1 Introduction Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis that is characterized by prominent mesangial deposits of IgA (Rajasekaran et al., 2021).
1 Introduction Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic and led to coronavirus disease-2019 (COVID-19). In COVID-19, damage to multiple organs caused by SARS-CoV-2 infection hampers treatment and nursing, and increases the mortality risk (Puelles et al., 2020; Xu et al., 2020). Discovering relevant therapeutic candidates that can alleviate such organ damage is a very challenging and unmet need.
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