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Articles by William Mellick
Evidence for anterior cingulate cortex glutathione levels as a biomarker of oxidative stress and antioxidant response in people with bipolar disorder
Abstract Glutathione (GSH), the brain’s primary antioxidant, confers a critical first line of defense against oxidative-stress-induced cellular damage, with some evidence supporting compensatory upregulation of anterior cingulate cortex (ACC) GSH in bipolar disorder (BD).
Glutamate- and GABA-targeted drugs for Cc-occurring bipolar and alcohol use disorders: a randomized, double-blind, placebo-controlled, crossover study of N-acetylcysteine, gabapentin, and placebo
Abstract Forty percent of people with bipolar disorder (BD) develop alcohol use disorder (AUD), with co-occurring AUD substantially worsening the course of BD. Though efficacious treatments remain elusive, frontal glutamate and GABA dysregulation represent promising targets for intervention.
Aberrant cortico-striato-limbic functional connectivity to alcohol cues in co-occurring bipolar disorder and alcohol use disorder
Abstract Reward brain circuitry dysfunction is a hypothesized mechanism of bipolar disorder and alcohol use disorder co-occurrence (BD + AUD) that remains largely untested. This neuroimaging study represents the first investigation of functional connectivity in BD + AUD. Following a two-by-two factorial design (N = 90), individuals with BD + AUD (n = 22), AUD alone (n = 20), BD alone (n = 23), and healthy control participants (n = 25) were administered a fMRI alcohol-cue reactivity paradigm.
Alcohol Cue Processing in Co-Occurring Bipolar Disorder and Alcohol Use Disorder
Key Points Question How is alcohol cue processing in individuals with co-occurring bipolar disorder and alcohol use disorder (BD + AUD) distinct from that of individuals with AUD or BD alone? Findings In this case-control study that used a 2 × 2 factorial functional neuroimaging design, individuals with BD + AUD were uniquely characterized by reduced alcohol cue-elicited brain activation within the right inferior frontal gyrus, insula, and dorsal striatum.
Results from a randomized, double‐blind, placebo‐controlled, crossover, multimodal‐MRI pilot study of gabapentin for co‐occurring bipolar and cannabis use disorders
ORIGINAL ARTICLE James J. Prisciandaro, Corresponding Author priscian@musc.edu orcid.org/0000-0002-8877-7871 Addiction Sciences Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA Correspondence James J. Prisciandaro, Addiction Sciences Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA.
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