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Abstract Leukemia, the most common malignancy in childhood, affects individuals from prepubertal girl to women of reproductive age. It originates from immature hematopoietic cells in the bone marrow and disseminates systemically via the blood and lymphatic circulations. Although survival rates have improved substantially, standard treatments, including intensive chemotherapy and hematopoietic stem cell transplantation, often combined with total body irradiation, are highly gonadotoxic.
1 Introduction CAC is a complex, multifactorial metabolic disorder [1, 2] and a major contributor to morbidity and mortality in the advanced stages of various cancers, including pancreatic, gastric, oesophageal, lung, colorectal, liver, head and neck, ovarian, leukaemia, lymphoma and sarcoma [3-6]. Characterized by involuntary weight loss, CAC leads to severe frailty due to skeletal muscle atrophy, adipose tissue depletion and organ dysfunction [7, 8].
1 Introduction Gametogenesis is a delicate and complex process (1). In female mammals, the primordial germ cells (PGCs) migrate to the gonad and form into cysts by rapidly dividing. Subsequently, oocytes initiate meiosis, cysts are breakdown (CBD), and primordial follicles (PFs) are assembled (2).
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