Originally publishedhttps://doi.org/10.1161/CIRCULATIONAHA.122.060375Circulation. 2022;146:1823–1835 Other version(s) of this article Abstract Background: Takotsubo syndrome is an acute cardiac emergency characterized by transient left ventricular systolic dysfunction typically following a stressful event. Despite its rapidly rising incidence, its pathophysiology remains poorly understood. Takotsubo syndrome may pass unrecognized, especially if timely diagnostic imaging is not performed.