Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the of this article. Supporting Information Filename Description exd70211-sup-0001-FigureS1-S16.docxWord 2007 document , 1.9 MB Figure S1: MR analysis of causal effect of HERC5 on SLE. Forest plot: Reflection of effect sizes for individual SNPs (black markers) and overall estimates (red markers) using IVW and MR Egger methods.