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Articles by Xiaochen Bai
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells - Nature Chemical Biology
Abstract Gain-of-function mutations of isocitrate dehydrogenase 1 (IDH1) lead to oncometabolite (R)-2-hydroxyglutarate production, contributing to the tumorigenesis of multiple human cancers. While fatty acid biosynthesis is critical for IDH1-mutant tumor growth, the underlying mechanisms remain unclear. Here, leveraging chemical probes and chemoproteomic profiling, we identified that oncogenic IDH1-R132H is uniquely autopalmitoylated at C269, which is not observed in wild-type IDH1.
Structural basis for Retriever-SNX17 assembly and endosomal sorting - Nature Communications
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Abstract During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction have remained elusive. Here, we provide biochemical, structural, cellular, and proteomic analyses of the SNX17-Retriever interaction.
By Amika Singla, Ran Song, Daniel Kramer Verified, Andrew Lemoff, Xiaochen Bai, Zhe Chen, Ezra Burstein, Emre E. Turer
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Nature
Verified
Reply to: The G protein preference of orexin receptors is currently an unresolved issue - Nature Communications
replying to J. P. Kukkonen Nature Communications https://doi.org/10.1038/s41467-023-38764-3 (2023) Kukkonen challenges our interpretation of data in Figure 5d of our paper1. In this experiment, we co-transfected HEK293 cells with CMV-driven overexpression plasmids for OX2R and Gαi1 along with a pGloSensor cAMP reporter construct, and measured diminished cAMP levels with OX2R agonists after forskolin stimulation.
Sensory specializations drive octopus and squid behaviour - Nature
van Giesen, L., Kilian, P. B., Allard, C. A. H. & Bellono, N. W. Molecular basis of chemotactile sensation in octopus. Cell 183, 594–604.e14 (2020). Article PubMed PubMed Central Google Scholar Noviello, C. M. et al. Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell 184, 2121–2134 (2021). Article CAS PubMed PubMed Central Google Scholar Albertin, C. B. et al. The octopus genome and the evolution of cephalopod neural and morphological novelties. Nature 524, 220–224 (2015).
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