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Articles by Xiaodi Yang
Disruption of ACTG1 potentiates anti-TIM-3 immunotherapy by reprogramming the immunosuppressive microenvironment via the CSF3/CSF3R axis in pancreatic cancer
Abstract Background: The limited immune infiltration observed in pancreatic ductal adenocarcinoma (PDAC) is a major factor contributing to immunotherapy resistance and the consistently poor prognosis. Hence, identifying novel therapeutic targets and developing effective combination strategies to overcome immunotherapy resistance represent urgent and unmet clinical needs. Methods: The gene expression datasets and corresponding clinical information were collected from TCGA, GEO and ICGC.
Thy1 retroviral reporters: a versatile platform for congenic background-independent adoptive transfer and CD8 + T cell differentiation studies
Abstract Adoptive T cell transfer remains a fundamental technique for dissecting the molecular mechanisms governing T cell differentiation. A successful adoptive-transfer experiment typically relies on labor-intensive construction of specific congenic mouse strains to distinguish donor from host cells. This limitation may be addressed by a readily detectable surface reporter.
N‐Heterocyclic Carbene‐Catalyzed Asymmetric Cyclization of Cyclohexadienone‐Tethered Ynals to Stereodivergent 6,5‐Bicyclic and 6,5,5‐Tricyclic Products
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description ejoc202500305-sup-0001-SuppData-S1.pdf6.1 MB Supplementary Material References 1, , in Topics in Stereochemistry, Vol. 18 (Eds.: E. L. Eliel, S. H. Wilen), John Wiley & Sons, inc., New York, 1988, pp. 249–330. , , in Esterification: Methods, Reactions, and Applications, 2nd (Eds.: J. Otera, J. Nishikido), WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2010, pp. 195–225. c) , , Angew. Chem. Int.
Synthesis of enantioenriched spirocyclic oxindole catalyzed by bifunctional thiourea
Synthesis of enantioenriched spirocyclic oxindole catalyzed by bifunctional thiourea The spirocyclic oxindole scaffold, prevalent in natural products and bioactive compounds, holds paramount significance in organic chemistry. We report an efficient strategy for the construction of enantioenriched spirocyclic oxindoles bearing four consecutive stereogenic centers via a Michael–Mannich cascade reaction catalyzed by a bifunctional thiourea.
TIM8 Deficiency in Yeast Induces Endoplasmic Reticulum Stress and Shortens the Chronological Lifespan
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Genomic differences of patients with hematologic malignancies in different age groups - Communications Biology
Abstract Hematologic malignancies cause significant morbidity/mortality in both children and young adults (CYAs) as well as older adults (OAs). Yet their biological underpinnings remain inadequately understood. Here, we analyzed clinical and genomic disparities between CYAs and OAs in various hematologic malignancies. We found substantial differences in clinical features such as patient sex, ethnicity, metastasis rates, and tumor subtypes.
Azulene‐Embedded [n]Helicenes (n = 5, 6 and 7)
Research Article Chao Duan, Chao Duan SIOC: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, CHINA Search for more papers by this author Jianwei Zhang, Jianwei Zhang Shanghai University of Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, CHINA Search for more papers by this author Junjun Xiang, Junjun Xiang SIOC: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, CHINA Search for more papers by this author...
Dithieno[3,2-a:3′,2′-j][5,6,11,12]chrysene diimides based polymer as electron transport layer for efficient inverted perovskite solar cells
Dithieno[3,2-a:3′,2′-j][5,6,11,12]chrysene diimides based polymer as electron transport layer for efficient inverted perovskite solar cells Jintao Huang, Fei Qin, Jianwei Zhang, Xiaodi Yang, Ye Zou, Yinhua Zhou, Wei-Shi Li, Cong-Wu Ge and Xike Gao Abstract Electron transport layer (ETL) plays an important role in promoting both photovoltaic performance and stability of perovskite solar cells (PSCs).
Incorporation of 2,6-Connected Azulene Units into the Backbone of Conjugated Polymers towards High-Performance Organic Optoelectronic Materials
Azulene is considered to be a promising candidate for constructing optoelectronic materials. We present herein an effective strategy to obtain high performance conjugated polymers by incorporating 2,6-connected azulene units into the polymeric backbone, and two conjugated copolymers P(TBAzDI-TPD) and P(TBAzDI-TFB) are designed and synthesized based on this strategy.
A Non-enzymatic Electrochemical Biosensor Based on SiO2-Au Nanoparticles for Hemoglobin Detection
In this case, a simple non-enzymatic hemoglobin (Hb) biosensor with the help of SiO2-Au nanoparticles (SiO2-Au NPs) was prepared and investigated. The structure and morphology of SiO2-Au NPs were characterized by transmission electron microscope (TEM) and UV-vis.
Biazulene diimides: a new building block for organic electronic materials
Azulene, a 10-π-electron isomer of naphthalene, is a nonbenzenoid bicyclic aromatic hydrocarbon with a beautiful blue color and a large dipole moment. We present here the first class of azulene-based aromatic diimides, 2,2′-biazulene-1,1′,3,3′-tetracarboxylic diimides (BAzDIs), which comprise a 2,2′-biazulene moiety and two seven-membered imide groups.
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