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CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description ijc34892-sup-0001-Supinfo.pdfPDF document, 1.3 MB Data S1. Supporting information. ijc34892-sup-0002-Tables.xlsxExcel 2007 spreadsheet , 47 KB Data S2. Supporting information. REFERENCES 1, . Familial lymphoma: review of the literature and report of two brothers with lymphosarcoma. Bol Asoc Med P R. 1961; 53: 325-337. 2, , , , .
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description ijc34892-sup-0001-Supinfo.pdfPDF document, 1.3 MB Data S1. Supporting information. ijc34892-sup-0002-Tables.xlsxExcel 2007 spreadsheet , 47 KB Data S2. Supporting information. REFERENCES 1, . Familial lymphoma: review of the literature and report of two brothers with lymphosarcoma. Bol Asoc Med P R. 1961; 53: 325-337. 2, , , , .
T cells undergo homeostatic expansion and acquire an activated phenotype in lymphopenic microenvironments. Restoration of normal lymphocyte numbers typically re-establishes normal homeostasis, and proinflammatory cytokine production returns to baseline. Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysregulated homeostatic expansion, which manifests as lymphoproliferative disease with autoantibody production.
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