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Conflicts of interest The authors declare that they have no conflicts of interest. References 1 & (2024) A guide to cell death pathways. Nat Rev Mol Cell Biol 25, 379–395. 2 & (2022) No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death. Biochem J 479, 1083–1102. 3, & (2016) The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases. Nat Rev Rheumatol 12, 543–558.
The Nuclear Factor-?B (NF-?B) family of transcription factors play an essential role for the regulation of inflammatory responses, immune function and malignant transformation. Aberrant activity of this signaling pathway may lead to inflammation, autoimmune diseases and oncogenesis. Over the last two decades great progress has been made in the understanding of NF-?B activation and how the response is counteracted for maintaining tissue homeostasis.
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