Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China Introduction: The coexistence of the MOG antibody (MOG-ab) and NMDAR antibody (NMDAR-ab), which is known as the MOG-ab and NMDAR-ab overlapping syndrome (MNOS), is the most common in overlapping syndromes of neural autoantibodies. The study aimed to analyze the clinical features and outcomes in adult patients suffering from MNOS and investigate the mechanisms of the disorder.