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Xiaoke Xing

As seen in: Nature, BioRxiv
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Articles by Xiaoke Xing

Arginine methylation coordinates with phosphorylation to control NADP + synthesis

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By Yue Zhu, Wanjun Zhang, Qian Li, Mengxue Hu, Xiaoke Xing, Yanze Li, Hemeng Zhang, Yuanyuan Zhao, Chunmin Zhang, Yali Chen, Juanjuan Li, Weijie Qin, Suxia Han, Huadong Pei, Pingfeng Zhang, Feng Yao, Luojun Chen
| Nature Verified
Abstract The NAD(H)/NADP(H) ratio is essential for maintaining cellular redox homeostasis. NAD kinase (NADK) is the sole cytosolic enzyme responsible for converting NAD+ to NADP+. Dysregulation of NADK has been linked to aging and cancer; however, the underlying regulatory mechanisms remain poorly understood. Here, we show that NADP+ synthesis is markedly suppressed in mice fed a high-fat diet.
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Arginine methylation coordinates with phosphorylation to regulate NADP+ synthesis

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By Yue Zhu, Wanjun Zhang, Mengxue Hu, Xiaoke Xing
| BioRxiv
Abstract NADK is the sole cytosolic enzyme responsible for synthesizing NADP+ from NAD+ within cells. The homeostasis of NAD+/NADP+ is controlled by NADK, usually dysregulated in various cancers, yet the precise underlying regulatory mechanisms remain largely unknown. In this study, we discover that PRMT6 methylates NADK at R39, R41, and R45, resulting in the suppression of NADK kinase activity and NADP+ synthesis. Mutations of these sites promote cancer cell proliferation and tumor growth.
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