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Articles by Xiaolin He
Improving the precision of AAV lung gene therapy for SP-B deficiency using computationally derived lung-specific promoters Original
Abstract Recombinant adeno-associated virus (rAAV) platforms have achieved significant success in clinical gene therapy; however, many still rely on ubiquitous promoters. This robust and widespread transgene expression can cause off-target effects, immune activation, and systemic toxicity, limiting their suitability for diseases requiring tissue-specific expression, such as surfactant protein B (SP-B) deficiency.
Cr(III) Oxidation/Fixation by Fe‐Mn Oxides From Mn(II) Oxidation on Al‐Substituted Ferrihydrite at Neutral/Alkaline pH
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description ejss70275-sup-0001-Supinfo.docxWord 2007 document , 350.5 KB Data S1: Supporting information. References , , , et al. 2013. “Arsenic Scavenging by Aluminum-Substituted Ferrihydrites in a Circumneutral pH River Impacted by Acid Mine Drainage.” Environmental Science & Technology 47: 12784–12792.
CIMinus: Empowering Sparse DNN Workloads Modeling and Exploration on SRAM-based CIM Architectures
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Erratum for the Research Article “ALK is a therapeutic target for lethal sepsis” by L. Zeng et al.
Skip to main content Main content starts here In the Research Article “ALK is a therapeutic target for lethal sepsis” by L. Zeng et al., there were duplication errors in Fig. 2, G and H, and fig. S5, A to C. The blot for p-IRF3 in the right column of Fig. 2G and the blots for IRF3 and p-p65 in the left column of Fig. 2H have been corrected. The S6 blot and the STING blot have been corrected in fig. S5, B and C, respectively. The other data and conclusions in the manuscript are not affected.
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans
Editor’s summary Some kidney diseases, including crescentic glomerulonephritis, have abnormal epithelial cell proliferation in glomeruli. The mechanisms underlying this proliferation are not fully understood, and current treatments are not always effective. In a pair of papers, He et al. and Turinsky et al. show how Yes-associated protein (YAP) activation contributes to glomerular epithelial disease. He et al.
A cationic polymer drives glycosaminoglycan assembly and secretion for preclinical osteoarthritis therapy
Editor’s summary Glycosaminoglycans (GAGs) are negatively charged polysaccharides within the cartilage matrix that help maintain joint mechanical properties. Osteoarthritis results in the disruption of critical extracellular matrix components in cartilage. Here, Chen et al. demonstrate that the cationic polymer hexadimethrine bromide (HDMBr) can stimulate the production of GAGs by mesenchymal stem cells through mechanisms involving intracellular GAG condensation and secretion.
Metabolic surgery reduces CRC disease progression through circulating bile acid diversion
Editor’s summary Roux-en-Y gastric bypass (RYGB) surgery decreases subsequent colorectal cancer (CRC) risk, but the reasons behind this effect are unclear. Lässle et al. used a combined RYGB-CRC mouse model to show that the cancer-protective effect of the surgery was associated with bile acid diversion rather than with changes to immune cells, the microbiome, or weight loss per se.
Podocyte-specific YAP activation triggers crescentic glomerulonephritis through cross-talk with parietal epithelial cells
Editor’s summary Some kidney diseases, including crescentic glomerulonephritis, have abnormal epithelial cell proliferation in glomeruli. The mechanisms underlying this proliferation are not fully understood, and current treatments are not always effective. In a pair of papers, He et al. and Turinsky et al. show how yes-associated protein (YAP) activation contributes to glomerular epithelial disease. He et al.
The Combined Application of Inorganic and Organic Materials over Two Years Improves Soil pH, Slightly Increases Soil Organic Carbon, and Enhances Crop Yields in Severely Acidic Red Soil
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging
在这里添加一些文本 RIS (ProCite, Reference Manager) BibTeX Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches Aging and disease ›› 2026, Vol. 17 ›› Issue (3) : 1399-1422.
The Effects of Tea Polyphenols in Feed on the Immunity, Antioxidant Capacity, and Gut Microbiota of Weaned Goat Kids
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Novel Fe2O3/PZT Nanorods for Ferroelectric Polarization-Enhanced Photoelectrochemical Water Splitting
As an ideal photocatalyst in the photoelectrochemical (PEC) water oxidation area, hematite (α-Fe2O3) has received much attention from scientists on account of its favorable band gap and excellent stability in alkaline media. However, the practical photocurrent yield of α-Fe2O3 is much less than the theoretical value because of the high charge recombination and the low charge transport.
Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement
Original research article Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement Kenichiro Yamamura1, Darren Yuen2,3, Edward J Hickey1,4, Xiaolin He2,3, Rajiv R Chaturvedi5, Mark K Friedberg5, Lars Grosse-Wortmann5,6, Kate Hanneman7, Filio Billia1, Michael E Farkouh1, Rachel M Wald1,3,5,7 1 Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada 2 Division of...
Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement
Objective The relationship between right ventricular (RV) fibrosis and right heart reverse remodelling following pulmonary valve replacement (PVR) has not been well studied in adults with repaired tetralogy of Fallot (rTOF). Our aims were to histologically quantify RV fibrosis and to explore the relationship between fibrosis severity and cardiac remodelling post-PVR. Methods Adults with rTOF and pre-PVR cardiovascular (CMR) imaging were consented to procurement of RV muscle during PVR.
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