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Keywords ESRRB ERK embryonic stem cells self-renewal XEN differentiation Introduction Embryonic stem cells (ESCs) are pluripotent stem cells (PSCs) derived from the inner cell mass of the blastocyst (Evans and Kaufman, 1981; Martin, 1981). The indefinite in vitro self-renewal capacity and the differentiation potential into all cell types in the body, known as pluripotency, render ESCs as a promising source of donor cells for regenerative medicine.
Abstract Erk signaling is indispensable for the self-renewal and differentiation of mouse embryonic stem cells (ESCs), as well as telomere homeostasis. But how Erk regulates these biological processes remains unclear. We identified 132 Erk2 interacting proteins by co-immunoprecipitation and mass spectrometric analysis, and focused on Ddx39 as a potential Erk2 substrate. We demonstrated that Erk2 phosphorylates Ddx39 on Y132 and Y138.
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