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Abstract Glucoamylase is essential for industrial starch saccharification, but the limited thermostability and near-neutral pH tolerance of fungal glucoamylases necessitate cooling and acidification of liquefied starch. Here, we developed an artificial intelligence-guided strategy to simultaneously improve the thermostability, pH tolerance, and catalytic activity of glucoamylase from Penicillium oxalicum (PoGA).
1 Introduction Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS) primarily affecting young adults and characterized by oligodendrocyte loss and insufficient remyelination [1]. Although current immunomodulatory therapies mitigate inflammatory lesions, they fail to promote functional repair of demyelinated axons or halt progressive neurodegeneration.
1. Introduction 1.1. Research Significance In recent years, with the increasing development of maritime transportation, the rate of maritime accidents has been increasing on an annual basis, especially the number of collisions. The European Maritime Safety Agency (EMSA) released an annual overview of marine accidents and incidents in 2022, in which a total of 4869 collision accidents and groundings occurred from 2014 to 2022. This accounted for 45.8% of the total number of accidents.
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Research Article Synthesis of highly transparent and heat‐resistant polyimides containing bulky pendant moieties Qi Wu School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai, 200240 P. R.
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