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Xiaozhen He

As seen in: The BMJ, The Journal of Immunology
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Articles by Xiaozhen He

Clonal reshaping and clinical outcomes after rechallenge in ICI-associated myocarditis: integrated single-cell and TCR repertoire analysis

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By Jian Zhang, Xiaozhen He, Yerui Zhang
| The BMJ Verified
It is known that immune checkpoint inhibitor-associated myocarditis (ICIAM), while rare, carries a high mortality rate, leading major clinical guidelines (eg, American Society of Clinical Oncology, European Society of Cardiology) to recommend permanent discontinuation of immune checkpoint inhibitor (ICI) therapy once diagnosis.
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Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide

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By Xiaozhen He, Shandong Academy, Ruiling Liu, Shenzhen Institutes
| The Journal of Immunology Verified
Xiaozhen He, Ruiling Liu, Tingting Fan, Xiaowen Huang, Chunlei Wu, Wu Su, Ting Wang and Qingguo Ruan J Immunol April 15, 2020, 204 (8) 2053-2063; DOI: https://doi.org/10.4049/jimmunol.1901215 Key Points Polyamide targeting IL-23 specifically inhibits the expression of IL-23. Polyamide targeting IL-23 is effective in treating psoriasis and EAU in mice. Abstract Autoimmune diseases are a physiological state that immune responses are directed against and damage the body’s own tissues.
Open in Who Shared Issue with article?

Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide

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By Shandong Academy, Ruiling Liu, Shenzhen Institutes, Xiaozhen He
| The Journal of Immunology Verified
Xiaozhen He, Ruiling Liu, Tingting Fan, Xiaowen Huang, Chunlei Wu, Wu Su, Ting Wang and Qingguo Ruan J Immunol March 13, 2020, ji1901215; DOI: https://doi.org/10.4049/jimmunol.1901215 Key Points Polyamide targeting IL-23 specifically inhibits the expression of IL-23. Polyamide targeting IL-23 is effective in treating psoriasis and EAU in mice. Abstract Autoimmune diseases are a physiological state that immune responses are directed against and damage the body’s own tissues.
Open in Who Shared Issue with article?
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