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Abstract The ongoing SARS-CoV-2 evolution is constrained by population-level immune imprinting. Recent genomic surveillance revealed an unexpected demographic shift with the Omicron sublineage BA.3.2.2 being predominant in paediatric populations globally. Here we show that this paediatric susceptibility arises from the absence of immune imprinting against ancestral SARS-CoV-2 Wuhan strain.
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