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Abstract Chiral amines are indispensable building blocks in pharmaceutical synthesis. (R)-3-([1,1′-biphenyl]-4-yl)-2-aminopropan-1-ol (ABP), a key chiral amine intermediate of the drug Entresto, has remained difficult to access via enzymatic asymmetric synthesis due to the inability of ω-transaminases to accommodate its bulky ketone precursor.
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