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Abstract Targeting the lateral habenula (LHb), a key brain region regulating alcohol consumption, presents a promising framework for reducing drinking. LHb neurons exhibit high sensitivity and responsiveness to the intravenous anesthetic propofol. However, whether and how propofol-activated habenular neurons regulate alcohol drinking remains unknown. Here, we show that a single dose of propofol rapidly and persistently reduces alcohol consumption in mice for approximately six days.
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