Abstract The convergent hydrogen bonding motif of phosphotyrosine residues of proteins has inspired an advanced strategy for the design of a new type of anionocage based on (RPO32−)-monourea coordination, which features more simple synthesis and more potential of functionalization than the former strategy based on (PO43−)-bisurea coordination, providing a proof of the design concept “Less is More”. Abstract Anionocages have been developed as a unique family of hydrogen bonded cages.
