1 Introduction Bisphosphonates (BPs) are widely used to treat bone resorptive diseases such as osteoporosis, Paget's disease, cancer bone metastases, and multiple myeloma.[1-4] They inhibit bone resorption by binding to mineralized bone surfaces and suppressing osteoclast activity through farnesyl diphosphate synthase (FDPS) inhibition in the mevalonate pathway.[5] However, prolonged use of potent BPs, such as zoledronic acid (ZA), can lead to a severe complication known as...
