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Articles by Xiuling Cao
Synthesis and properties of isocyanate-functionalized isosorbide high heat-resistant copolyesters
Synthesis and properties of isocyanate-functionalized isosorbide high heat-resistant copolyesters In this work, conventional poly(ethylene glycol-1,4-cyclohexanedimethanol terephthalate) (PCTG) was modified by functionalizing isosorbide (ISB) with isophorone diisocyanate (IPDI).
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
eLife Assessment By combining Synthetic Genetic Array (SGA) analysis with state-of-the-art imaging techniques, this study provides strong evidence that sphingolipid metabolism controls the maturation of Parkinson's disease-associated Synphilin-1 inclusion bodies (SY1 IBs) on the mitochondrial surface in a yeast model. The authors present compelling proof that perturbing the sphingolipid metabolic pathway leads to delayed SY1 IB maturation and enhanced SY1-triggered toxicity.
Unveiling the Longevity Potential of Natural Phytochemicals: A Comprehensive Review of Active Ingredients in Dietary Plants and Herbs
1. Introduction Click to copy section linkSection link copied! Aging is a cellular stress response triggered by molecular damage, which ultimately results in an imbalance within the body. This is an inevitable progression toward dysfunction and eventual death across most living organisms, particularly mammals. As aging progresses, there is accumulation of damage that increases disease susceptibility and mortality. Why and how we age remains a mystery.
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
Abstract Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a yeast imaging-based screen, we identified 84 potential synphilin-1 (SY1) IB regulators and isolated the conserved sphingolipid metabolic components in the most enriched groups. Furthermore, we show that, in both yeast cells and mammalian cells, SY1 IBs are associated with mitochondria.
Plant-derived extracts and metabolic modulation in leukemia: a promising approach to overcome treatment resistance
Cindy Mayerli Arévalo1, Nataly Cruz-Rodriguez2, Sandra Quijano1 and Susana Fiorentino1* 1Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia 2Versiti Blood Research Institute, Milwaukee, WI, United States Leukemic cells acquire complex and often multifactorial mechanisms of resistance to treatment, including various metabolic alterations.
Materials | Free Full-Text | Comparison of the Mechanical Properties and Crack Expansion Mechanism of Different Content and Shapes of Brass-Coated Steel Fiber-Reinforced Ultra-High-Performance Concrete
Open AccessArticle by Yanli Jiang 1,2,3, Yulong Yan 1,2,3, Tianran Li 1,2,3, Xiuling Cao 4,5,*, Liang Yu 1,2,3,* and Haiquan Qi 1,2,3 1 Key Laboratory of New Processing Technology for Nonferrous Metals & Materials, Guilin University of Technology, Guilin 541004, China 2 Guangxi Key Laboratory of Optical and Electronic Materials and Devices, Guilin 541004, China 3 Guangxi Modern Industry College of Innovative Development in Nonferrous Metal Material, Guilin 541004, China 4 Hebei Technology...
The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator
Abstract : The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The spatiotemporal regulation mechanisms of APC/C in distinct cell cycle transitions are no longer mysterious, and the components of this protein complex are gradually identified and characterized.
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