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Xiuqiang Ma

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Articles by Xiuqiang Ma

Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody

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By Yonghu Sun, Zihao Mi, Yueqian Yu, Zhenzhen Wang, Lele Sun, Jianke Li, Baoqi Yang, Xiuhuan Wang, Yilei Wu, Kexin Liu, Xiaochen Ren, Jing J. Liu, Hong Luan, Guowei Zhao, Jian Shi, Chi Ma, Yongxia Liu, Mingkai Zhang, Peng Song, Peng Qu, Jianfeng Wang, Na Wang, Yue Xin, Qingqing Guo, Weizhi Wu, Hongqing Tian, Xuehui Li, Guoyuan Peng, Xuan Guo, Guangliang Zhang, Benke Li, Xiaoxiao Yan, Jianwen Wang, Jiabao You, Gongqi Yu, Chuan Wang, Xiaopei Cui, Yifan Zhan, Xiangyang Zhu, Hong liu, Furen Zhang, Minkuo Zhang, Wenwen Sai, Xiuqiang Ma
| Nature Verified
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with a high unmet need, particularly for treatment-resistant tunnels. Integrated multiomics analysis revealed that HS tunnels are spatially organized, self-amplifying inflammatory circuits driven by synergistic IL-17/IL-36γ activation of a unique keratinocyte subset, which activates neutrophils and inflammatory fibroblasts.
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